Radiation protection of staff in 111In radionuclide therapy--is the lead apron shielding effective?
Identifieur interne : 001177 ( Main/Exploration ); précédent : 001176; suivant : 001178Radiation protection of staff in 111In radionuclide therapy--is the lead apron shielding effective?
Auteurs : RBID : pubmed:21816731English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Indium Radioisotopes.
- instrumentation : Radiation Protection.
- prevention & control : Occupational Exposure.
- Health Personnel, Humans, Lead, Male, Phantoms, Imaging, Protective Clothing, Radiotherapy Dosage, Thermoluminescent Dosimetry, Whole-Body Counting.
Abstract
(111)In (Eγ = 171-245 keV, t1/2 = 2.83 d) is used for targeted therapies of endocrine tumours. An average activity of 6.3 GBq is injected into the liver by catheterisation of the hepatic artery. This procedure is time-consuming (4-5 min) and as a result, both the physicians and the technical staff involved are subjected to radiation exposure. In this research, the efficiency of the use of lead apron has been studied as far as the radiation protection of the working staff is concerned. A solution of (111)In in a cylindrical scattering phantom was used as a source. Close to the scattering phantom, an anthropomorphic male Alderson RANDO phantom was positioned. Thermoluminescent dosemeters were located in triplets on the front surface, in the exit and in various depths in the 26th slice of the RANDO phantom. The experiment was repeated by covering the RANDO phantom by a lead apron 0.25 mm Pb equivalent. The unshielded dose rates and the shielded photon dose rates were measured. Calculations of dose rates by Monte Carlo N-particle transport code were compared with this study's measurements. A significant reduction of 65 % on surface dose was observed when using lead apron. A decrease of 30 % in the mean absorbed dose among the different depths of the 26th slice of the RANDO phantom has also been noticed. An accurate correlation of the experimental results with Monte Carlo simulation has been achieved.
DOI: 10.1093/rpd/ncr330
PubMed: 21816731
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiation protection of staff in 111In radionuclide therapy--is the lead apron shielding effective?</title><author><name sortKey="Lyra, M" uniqKey="Lyra M">M Lyra</name><affiliation wicri:level="1"><nlm:affiliation>Medical Physics Unit, A' Radiology Department, University of Athens, Aretaieion Hospital, Athens 11528, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Medical Physics Unit, A' Radiology Department, University of Athens, Aretaieion Hospital, Athens 11528</wicri:regionArea></affiliation></author><author><name sortKey="Charalambatou, P" uniqKey="Charalambatou P">P Charalambatou</name></author><author><name sortKey="Sotiropoulos, M" uniqKey="Sotiropoulos M">M Sotiropoulos</name></author><author><name sortKey="Diamantopoulos, S" uniqKey="Diamantopoulos S">S Diamantopoulos</name></author></titleStmt><publicationStmt><date when="2011">2011</date><idno type="doi">10.1093/rpd/ncr330</idno><idno type="RBID">pubmed:21816731</idno><idno type="pmid">21816731</idno><idno type="wicri:Area/Main/Corpus">001223</idno><idno type="wicri:Area/Main/Curation">001223</idno><idno type="wicri:Area/Main/Exploration">001177</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Health Personnel</term><term>Humans</term><term>Indium Radioisotopes (therapeutic use)</term><term>Lead</term><term>Male</term><term>Occupational Exposure (prevention & control)</term><term>Phantoms, Imaging</term><term>Protective Clothing</term><term>Radiation Protection (instrumentation)</term><term>Radiotherapy Dosage</term><term>Thermoluminescent Dosimetry</term><term>Whole-Body Counting</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Radiation Protection</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Health Personnel</term><term>Humans</term><term>Lead</term><term>Male</term><term>Phantoms, Imaging</term><term>Protective Clothing</term><term>Radiotherapy Dosage</term><term>Thermoluminescent Dosimetry</term><term>Whole-Body Counting</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">(111)In (Eγ = 171-245 keV, t1/2 = 2.83 d) is used for targeted therapies of endocrine tumours. An average activity of 6.3 GBq is injected into the liver by catheterisation of the hepatic artery. This procedure is time-consuming (4-5 min) and as a result, both the physicians and the technical staff involved are subjected to radiation exposure. In this research, the efficiency of the use of lead apron has been studied as far as the radiation protection of the working staff is concerned. A solution of (111)In in a cylindrical scattering phantom was used as a source. Close to the scattering phantom, an anthropomorphic male Alderson RANDO phantom was positioned. Thermoluminescent dosemeters were located in triplets on the front surface, in the exit and in various depths in the 26th slice of the RANDO phantom. The experiment was repeated by covering the RANDO phantom by a lead apron 0.25 mm Pb equivalent. The unshielded dose rates and the shielded photon dose rates were measured. Calculations of dose rates by Monte Carlo N-particle transport code were compared with this study's measurements. A significant reduction of 65 % on surface dose was observed when using lead apron. A decrease of 30 % in the mean absorbed dose among the different depths of the 26th slice of the RANDO phantom has also been noticed. An accurate correlation of the experimental results with Monte Carlo simulation has been achieved.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">21816731</PMID><DateCreated><Year>2011</Year><Month>10</Month><Day>31</Day></DateCreated><DateCompleted><Year>2012</Year><Month>02</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1742-3406</ISSN><JournalIssue CitedMedium="Internet"><Volume>147</Volume><Issue>1-2</Issue><PubDate><Year>2011</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Radiation protection dosimetry</Title><ISOAbbreviation>Radiat Prot Dosimetry</ISOAbbreviation></Journal><ArticleTitle>Radiation protection of staff in 111In radionuclide therapy--is the lead apron shielding effective?</ArticleTitle><Pagination><MedlinePgn>272-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/rpd/ncr330</ELocationID><Abstract><AbstractText>(111)In (Eγ = 171-245 keV, t1/2 = 2.83 d) is used for targeted therapies of endocrine tumours. An average activity of 6.3 GBq is injected into the liver by catheterisation of the hepatic artery. This procedure is time-consuming (4-5 min) and as a result, both the physicians and the technical staff involved are subjected to radiation exposure. In this research, the efficiency of the use of lead apron has been studied as far as the radiation protection of the working staff is concerned. A solution of (111)In in a cylindrical scattering phantom was used as a source. Close to the scattering phantom, an anthropomorphic male Alderson RANDO phantom was positioned. Thermoluminescent dosemeters were located in triplets on the front surface, in the exit and in various depths in the 26th slice of the RANDO phantom. The experiment was repeated by covering the RANDO phantom by a lead apron 0.25 mm Pb equivalent. The unshielded dose rates and the shielded photon dose rates were measured. Calculations of dose rates by Monte Carlo N-particle transport code were compared with this study's measurements. A significant reduction of 65 % on surface dose was observed when using lead apron. A decrease of 30 % in the mean absorbed dose among the different depths of the 26th slice of the RANDO phantom has also been noticed. An accurate correlation of the experimental results with Monte Carlo simulation has been achieved.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lyra</LastName><ForeName>M</ForeName><Initials>M</Initials><Affiliation>Medical Physics Unit, A' Radiology Department, University of Athens, Aretaieion Hospital, Athens 11528, Greece.</Affiliation></Author><Author ValidYN="Y"><LastName>Charalambatou</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Sotiropoulos</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Diamantopoulos</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Radiat Prot Dosimetry</MedlineTA><NlmUniqueID>8109958</NlmUniqueID><ISSNLinking>0144-8420</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>2P299V784P</RegistryNumber><NameOfSubstance>Lead</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="Y">Health Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Lead</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Phantoms, Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Protective Clothing</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiation Protection</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiotherapy Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Thermoluminescent Dosimetry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Whole-Body Counting</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2011</Year><Month>8</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">ncr330</ArticleId><ArticleId IdType="doi">10.1093/rpd/ncr330</ArticleId><ArticleId IdType="pubmed">21816731</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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